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Ganciclovir caused a dose-related decrease in body weight in bothrats and mice administered 10 mg/kg/day (approximately 1,600x the human ocular dose) for 28 days. In rats,those administered 15 mg/kg/day (2,400x the human ocular dose) and those administered 50 mg/kg/day(9,000x the human ocular dose) lost 50% and 25% of body weight and those administered 150 mg/kg/day(27,000x the human ocular dose) lost 90% of their body weight. In mice, those administered 150 mg/kg/day(27,000x the human ocular dose) lost 50% of their body weight. The effect in ratswas not due to anorexia or decreased food consumption.

Ganciclovir caused a decrease in body weight, body weight gain, and fat deposition in malemice administered 50 mg/kg/day (approximately 9x the human ocular dose) and 75 mg/kg/day (approximately12.5x the human ocular dose). Administration of 60 mg/kg/day (approximately 10x the human ocular dose)in male and female mice decreased food consumption and induced illness in females. Weight decreased for20 hours following a single dose of 10 mg/kg (approximately 1,600x the human ocular dose) in rats.

Ganciclovir caused testicular damage and a decrease in sperm count in male miceadministered 10 mg/kg/day (approximately 1,600x the human ocular dose) and 15 mg/kg/day (2,400xthe human ocular dose).

Ganciclovir caused a decrease in food consumption, weight loss, and/or vomiting inrats administered 90 mg/kg/day (approximately 14,000x the human ocular dose) for 28 days. Therats also experienced decreased activity, anorexia, decreased weight gain, increased water intake,increased respiratory rate, and desquamation of the paws.

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